Organized at Charlestown, Kent County, Md., October 2 to December 28, 1861. Attached to Dix's Division, Army of the Potomac, to March, 1862. Eastern Shore Maryland and Virginia Middle Department to July, 1862. District of Eastern Shore, 8th Army Corps, Middle Department, to March, 1863, 1st Separate Brigade, 8th Army Corps, to June, 1863. Lockwood's Brigade, 8th Army Corps, to July, 1863. 2nd Brigade, 1st Division, 12th Army Corps, Army of the Potomac, July, 1863. 2nd Brigade, Maryland Heights, Division West Virginia, to December, 1863. 2nd Brigade, 1st Division, West Virginia, to April, 1864. 1st Brigade, 1st Infantry, Division of West Virginia, to July, 1864. 2nd Brigade, 1st Infantry Division of West Virginia, to October, 1864. Reserve Division, District of Harper's Ferry, West Virginia, to February, 1865.
SERVICE.--Duty on eastern shore of Maryland until March, 1862, and at Baltimore until October, 1862. On eastern shore of Maryland until June, 1863, At Baltimore June, 1863. Joined Lockwood's Brigade at Frederick, Md., July 6, 1863. Pursuit of Lee July 6-14. Falling Waters July 14. Assigned to duty at Maryland Heights July 17. Duty there and guarding Baltimore & Ohio Railroad until April. 1864. Hunter's Expedition to Lynchburg, Va., May 26-July 1. Advance on Staunton May 26-June 6. Action at Piedmont and Mt. Crawford June 5. Occupation of Staunton June 6. Lexington June 12. Buchanan June 14. Liberty June 16. Lynchburg June 17-18. Retreat to the Ohio River June 19-July 1. Salem June 21. Moved to Shenandoah Valley July 1-17. Snicker's Gap July 18. Battle of Winchester July 24. Martinsburg July 25. Strasburg August 14-15. Bolivar Heights August 24. Berryville September 3. Guard duty in West Virginia until February, 1865. Consolidated with 1st Eastern Shore Infantry February 23, 1865.
Regiment lost during service 10 Enlisted men killed and mortally wounded and 1 Officer and 62 Enlisted men by disease. Total 73.